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. 2021 Jun 16;12(16):5013–5024. doi: 10.7150/jca.58023

Figure 3.

Figure 3

HNF1A regulated the apoptosis rate and cell cycle distribution of TE1 and KYSE150 ESCC cells. (A, B) The apoptosis rate in each group was detected by flow cytometry. (C) HNF1A relieved G0/G1 phase arrest in TE1 and KYSE150 ESCC cells after IR. (D) The histogram of cell cycle distribution was expressed as mean ± standard error for each group. (E) After IR, the proteins BAX/BCL2 were regulated by HNF1A in TE1 and KYSE150 cells. (F) HNF1A regulated cyclin D1/CDK4 to relieve G0/G1 phase arrest after IR. A comparison with the NC group is indicated by asterisks *P < 0.05, **P < 0.01 and ***P < 0.001; a comparison with the corresponding non-irradiated group is indicated by triangles ▲ P < 0.05, ▲▲P < 0.01 and ▲▲▲P < 0.001. HNF1A: hepatocyte nuclear factor 1-alpha; IR: irradiation.