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Proposed pathways for the oxidative bioactivation of carbamazepine in humans. The P450 isoforms shown are those reported to be the most active catalysts for the biotransformations. The depiction of the 2,3‐arene oxide as the sole product of aromatic epoxidation is purely representational; the number of arene oxides formed is unknown. The metabolic hydrolysis of carbamazepine 10,11‐epoxide is catalysed by microsomal epoxide hydrolase
