TABLE 4.
Distribution of single nucleotide polymorphisms (SNPs) amongst study subjects (n = 80)
| SNP ID | Gene | Allele | Genotype frequency (%) | Minor allele frequency | Hardy–Weinberg equilibrium (P) | ||
|---|---|---|---|---|---|---|---|
| Wild type | Heterozygote | Homozygote | |||||
| rs1045642 | ABCB1 | 3435C > T | 14 (17.5%) | 44 (55%) | 22 (27.5%) | 0.55 | .32 |
| rs1128503 | ABCB1 | 1236 T > C | 14 (17.5%) | 42 (52.5%) | 24 (30%) | 0.56 | .55 |
| rs2032582 | ABCB1 | 2677G > T | 24 (30.0%) | 39 (48.8%) | 17** (21.2%) | 0.46 | .88 |
| rs2273697 | ABCC2 | 1249G > A | 49 (61.3%) | 29 (36.3%) | 2 (2.4%) | 0.21 | .34 |
| rs3740066 | ABCC2 | 3972C > T | 25 (31.3%) | 42 (52.5%) | 13 (16.2%) | 0.43 | .51 |
| rs717620 | ABCC2 | –24C > T | 50 (62.5%) | 26 (32.5%) | 4 (5.0%) | 0.21 | .80 |
| rs28365062 | UGT2B7 | 735A > G | 62 (77.5%) | 18 (22.5%) | 0 (.0%) | 0.11 | .26 |
| rs28365063 | UGT2B7 | 372A > G | 56 (70.0%) | 24 (30.0%) | 0 (.0%) | 0.15 | .11 |
| rs7438135 | UGT2B7 | –900G > A | 27 (33.8%) | 39 (48.7%) | 14 (7.5%) | 0.42 | .99 |
| rs1051740 | EPHX1 | 337 T > C | 36 (45.0%) | 37 (46.3%) | 7 (8.7%) | 0.32 | .56 |
| rs2234922 | EPHX1 | 416A > G | 53 (66.3%) | 24 (30.0%) | 3 (3.7%) | 0.19 | .89 |
| rs11572080 | CYP2C8 | *3 | 62 (77.5%) | 16 (20.0%) | 2 (2.5%) | 0.13 | .44 |
| rs1058930 | CYP2C8 | *4 | 70 (87.5%) | 10 (12.5%) | 0 (.0%) | 0.06 | .55 |
| rs4244285 | CYP2C19 | *2 | 57 (71.3%) | 19 (23.7%) | 4 (5.0%) | 0.17 | .17 |
| rs192154563 | CYP2C19 | *17 | 80 (100%) | 0 (0.0%) | 0 (.0%) | 0.00 | NA |
| rs3745274 | CYP2B6 | *6 | 52 (65.0%) | 26 (32.5%) | 2 (2.5%) | 0.19 | .55 |
| rs2242480 | CYP3A4 | *1G | 71 (88.8%) | 9 (11.2%) | 0 (.0%) | 0.06 | .59 |
| rs776746 | CYP3A5 | *3 | 73 (91.3%) | 7 (8.7%) | 0 (.0%) | 0.04 | .68 |
| rs2333227 | MPO | –643G > A | 12 (15%) | 41 (51.3%) | 27 (33.7%) | 0.59 | .58 |
| rs1057868 | POR | *28 | 40 (50.0%) | 27 (33.8%) | 13 (16.2%) | 0.33 | .53 |
**
included 3 TA subjects, NA: not applicable.