FIGURE 5.

Distribution and conservation of CMT‐associated variant sites in human TrpRS. (a) Functional domains of TrpRS including a WHEP domain (in purple), a catalytic domain (in grey) and an anticodon domain (in yellow). (b) The crystal structure of human TrpRS (PDB entry 1R6T). CMT variant sites in either schematic diagram (a) or crystal structure (b) are indicated with different colors based on enzymatic activity of each variant with the same priority ranking as Figure 1b. (c) Evolutionary conservation analysis of CMT‐linked TrpRS across species. Sequence alignment of each variant site is indicated by the color intensity, with blue representing variable and red representing conserved