TABLE 1.
Description of the isolates used in this study
| Isolate | Description and references | Supplier |
|---|---|---|
| sCJD T1 | Type 1 sCJD M129M‐infected case (0.08.02523_001) 53 | BB a |
| sCJD T2/MDE‐HuTg340 | Terminally ill MDE‐HuTg340 mice infected with Type 2 sCJD V129 V‐infected case (BC1452) after two iterative passages | CISA b |
| vCJD | vCJD M129M‐infected case (BC1458) 54 | BHUFA c |
| C‐BSE | Classical BSE natural case from United Kingdom 55 | AHVLA d |
| H‐BSE | Atypical H‐BSE natural case from Poland. Po 45 56 | NVRI e |
| L‐BSE | Atypical L‐BSE natural case from Poland. Po 15 22 | NVRI |
| Scrapie 1 | Naturally scrapie‐infected goat from France (wt; S/P240). Fr−2143 57 | INRA f |
| Scrapie 2 | Naturally scrapie‐infected sheep from France (ARQ/ARQ). Fr‐PS21 24 | INRA |
| Scrapie 2/Tg110 | Terminally ill Bo‐Tg110 mice infected with Scrapie 2 | CISA |
| Scrapie 3 | Naturally scrapie‐infected (ARQ/ARQ) sheep from Italy. It−198–9 58 | ISS g |
| Scrapie 3/Tg110 | Terminally ill Bo‐Tg110 mice infected with Scrapie 3 | CISA |
| CWD | Naturally CWD infected Rocky Mountain elk. #3 | CFIA h |
a
Basque Biobank. Bilbao. Spain.
b
Centro de Investigación en Sanidad Animal, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria. Valdeolmos, Madrid, Spain.
c
CJD Reference Laboratory. Alcorcón. Spain.
d
Animal Health and Veterinary Laboratories Agency. New Haw. Addlestone. Surrey, UK.
e
National Veterinary Research Institute. Pulawy. Poland.
f
French National Institute for Agricultural Research, Nouzilly, France
g
Instituto Superiore di Sanitat. Rome. Italy.
h
National and OIE Reference Laboratory for Scrapie and CWD. Canadian Food Inspection Agency. Ottawa. Ontario, Canada.