TABLE 3.
Comparative transmission of sheep scrapie in MDE‐HuTg340 and VDQ‐HuTg372 mouse models before and after adaptation to cattle‐PrP amino acid sequence
| Prion origin | Inocula | Passage | Mean survival time in days ± SD, (n/n0) | |
|---|---|---|---|---|
| MDE‐HuTg340 | VDQ‐HuTg372 | |||
| Sheep | Scrapie 2 | 1st | >650 (0/6) a | 403 ± 20 (7/7) |
| 2nd | 369,579 (2/6) a | 378 ± 53 (6/6) | ||
| Scrapie 2/Bo‐Tg110 | 1st | 534 (1/5) | 555 (1/5) | |
| Scrapie 3 | 1st | >650 (0/6) | >650 (0/6) | |
| Scrapie 3/Bo‐Tg110 | 1st | >650 (0/6) | 576 ± 37 (6/6) | |
n/n0: diseased, PrPres positive/inoculated animals. Mean survival time is indicated for all mice scored positive for PrPres.
a
Published in reference. 24