Table 2.

Predictive value of RV longitudinal strain in pulmonary hypertension.

References	Sample size	RV free-wall/global GLS cut-off	Follow-up period (months)	Main findings
Motoji et al. (27)	42	−19.4%	48	RV free-wall longitudinal strain showed the best specificity and sensitivity in prediction of CV events in this population, significantly better than TAPSE, FAC, s′ and RV index of myocardial performance.
Park et al. (28)	51	−15.5%	45 ± 15	RV global longitudinal strain ≥-15.5% was independent predictor of adverse clinical events and mortality.
Fine et al. (29)	575	−15%	18	RV free-wall longitudinal strain predicted survival after adjustment for pulmonary pressure, pulmonary vascular resistance, and right atrial pressure.
Haeck et al. (30)	150	−19%	31	RV free-wall longitudinal strain, unlike TAPSE and FAC, was independent an predictor of all-cause mortality in these patients.
Badagliacca et al. (31)	108	–	24	The authors reported that the shape of the RV strain curve and the longer time necessary to return RV strain to the baseline point were associated with worse outcome.
Hardegree et al. (32)	50	−12.5%	48	≥5% improvement in RV free-wall longitudinal strain had >7-fold lower mortality during the follow-up of 4 years.
Hulshof et al. (33)	1,169	−19%	–	RV free-wall strain >-19% had a significantly higher risk for the combined endpoint (mortality and PAH-related events).
Leng et al. (34)	80	−25.2%	24	CMR-derived RV longitudinal strain, TAPSE, FAC, and RA longitudinal strain were predictors of adverse outcome in these patients.
Sato et al. (35)	21	–	9	Improvement of CMR-derived RV strain during ambrisentan and tadalafil combination therapy in PAH patients with systemic sclerosis.

CMR, cardiac magnetic resonance; CV, cardiovascular; FAC, fractional area change; GLS, global longitudinal strain; PAH, pulmonary arterial hypertension; RA, right atrium; RV, right ventricle; s′, systolic velocity of the lateral segment of tricuspid annulus; TAPSE, tricuspid annular plane systolic excursion.