Table 1.
Associations of clinical characteristics with MMR and KRAS status in all participants.
| MMR | KRAS | |||||
|---|---|---|---|---|---|---|
| pMMR | dMMR | P-Value | Wild-Type | Mutant-Type | P-Value | |
| Age (years) | 0.008 | 0.205 | ||||
| <65 | 1508 (91.28) | 144 (8.72) | 364 (66.30) | 185 (33.70) | ||
| >=65 | 594 (94.74) | 33 (5.26) | 144 (61.28) | 91 (38.72) | ||
| Gender | 0.914 | 0.43 | ||||
| Female | 840 (92.31) | 70 (7.69) | 197 (63.14) | 115 (36.86) | ||
| Male | 1262 (92.18) | 107 (7.82) | 311 (65.89) | 161 (34.11) | ||
| Histology type | 0.005 | 0.005 | ||||
| non-adenocarcinoma | 515 (89.41) | 61 (10.59) | 114 (56.44) | 88 (43.56) | ||
| adenocarcinoma | 1587 (93.19) | 116 (6.81) | 394 (67.70) | 188 (32.30) | ||
| Tumor size | <0.001 | 0.447 | ||||
| <=4.6cm | 1364 (96.40) | 51 (3.60) | 288 (63.58) | 165 (36.42) | ||
| >4.6cm | 738 (85.42) | 126 (14.58) | 220 (66.47) | 111 (33.53) | ||
| Tumor location | <0.001 | 0.009 | ||||
| Right | 448 (79.72) | 114 (20.28) | 142 (57.96) | 103 (42.04) | ||
| Left | 1654 (96.33) | 63 (3.67) | 366 (67.90) | 173 (32.09) | ||
| Degree of differentiation | <0.001 | 0.003 | ||||
| Low | 263 (86.80) | 40 (13.20) | 94 (77.69) | 27 (22.31) | ||
| Moderately and highly | 1719 (94.14) | 107 (5.86) | 382 (63.14) | 223 (36.86) | ||
| T stage | 0.025 | 0.229 | ||||
| I/II | 385 (95.06) | 20 (4.94) | 72 (70.59) | 30 (29.41) | ||
| III/IV | 1717 (91.62) | 157 (8.38) | 436 (63.93) | 246 (36.07) | ||
| Harvested lymph nodes | <0.001 | 0.842 | ||||
| <22 | 1508 (95.38) | 73 (4.62) | 318 (65.16) | 170 (34.84) | ||
| >=22 | 594 (85.10) | 104 (14.90) | 190 (64.19) | 106 (35.81) | ||
| Lymph nodes metastasis | <0.001 | 0.448 | ||||
| No | 1115 (89.27) | 134 (10.73) | 279 (66.11) | 143 (33.89) | ||
| Yes | 987 (95.83) | 43 (4.17) | 229 (63.26) | 133 (36.74) | ||
| Peripheral nerve invasion | <0.001 | 0.471 | ||||
| No | 1389 (89.67) | 160 (10.33) | 351 (65.73) | 183 (34.27) | ||
| Yes | 713 (97.67) | 17 (2.33) | 157 (62.80) | 93 (37.20) | ||
| Lymphovascular invasion | 0.047 | 0.755 | ||||
| No | 1588 (91.58) | 146 (8.42) | 402 (65.15) | 215 (34.84) | ||
| Yes | 514 (94.31) | 31 (5.69) | 106 (63.47) | 61 (36.53) | ||
| CEA | 0.022 | 0.033 | ||||
| Negative | 1189 (91.18) | 115 (8.82) | 301 (67.95) | 142 (32.05) | ||
| Positive | 875 (93.88) | 57 (6.12) | 197 (60.24) | 130 (39.76) | ||
| AFP | 1 | 1 | ||||
| Negative | 2041 (92.27) | 171 (7.73) | 64.66 | 35.34 | ||
| Positive | 23 (95.83) | 1 (4.17) | 66.67 | 33.33 | ||
| SCC | 1 | 0.337 | ||||
| Negative | 1943 (92.30) | 162 (7.70) | 460 (64.16) | 257 (35.84) | ||
| Positive | 121 (92.37) | 10 (7.63) | 38 (71.70) | 15 (28.30) | ||
| NSE | 0.559 | 0.419 | ||||
| Negative | 1352 (92.04) | 117 (7.96) | 295 (63.44) | 170 (36.56) | ||
| Positive | 712 (92.83) | 55 (7.17) | 203 (66.56) | 102 (33.44) | ||
| CA72-4 | <0.001 | 0.855 | ||||
| Negative | 1733 (93.73) | 116 (6.27) | 396 (64.92) | 214 (35.08) | ||
| Positive | 331 (85.53) | 56 (14.47) | 102 (63.75) | 58 (36.25) | ||
| CA125 | 0.479 | 0.179 | ||||
| Negative | 1865 (92.46) | 152 (7.54) | 441 (63.82) | 250 (36.18) | ||
| Positive | 199 (90.87) | 20 (9.13) | 57 (72.15) | 22 (27.85) | ||
| CA15-3 | 0.214 | 1 | ||||
| Negative | 2062 (92.34) | 171 (7.66) | 497 (64.63) | 272 (35.37) | ||
| Positive | 2 (66.67) | 1 (33.33) | 1 (100) | 0 (0) | ||
| CA199 | 1 | 0.006 | ||||
| Negative | 1671 (92.32) | 139 (7.68) | 408 (67.22) | 199 (32.78) | ||
| Positive | 393 (92.25) | 33 (7.75) | 90 (55.21) | 73 (44.78) | ||
| FERR | 0.143 | 0.181 | ||||
| Negative | 1942 (92.08) | 167 (7.92) | 467 (64.06) | 262 (35.94) | ||
| Positive | 122 (96.06) | 5 (3.94) | 31 (75.61) | 10 (24.39) | ||
| CYFRA21-1 | 1 | 0.9 | ||||
| Negative | 1525 (92.31) | 127 (7.69) | 366 (64.89) | 198 (35.11) | ||
| Positive | 539 (92.29) | 45 (7.71) | 132 (64.08) | 74 (35.92) | ||
Values presented are n (%) unless otherwise noted.