Table 3.

Univariate and multivariate analyses of various predictive factors for KRAS status in all participants.

	Univariate Analysis OR (95% CI)	P-Value	Multivariate Analysis OR (95%CI)	P-Value
Age (years)		0.177
<65	reference
>=65	1.243 (0.905~1.705)
Gender		0.43
Female	reference
Male	0.887 (0.658~1.196)
Histology type		0.004		0.067
non-adenocarcinoma	reference		reference
adenocarcinoma	0.618 (0.445~0.859)		0.696 (0.472~1.028)
Tumor size		0.403
<=4.6cm	reference
>4.6cm	0.881 (0.653~1.185)
Tumor location		0.007		0.012
Right	reference		reference
Left	0.652 (0.477~0.890)		0.645 (0.458~0.909)
Degree of differentiation		0.002		0.001
Moderately and highly	reference		reference
Low	0.492 (0.306~0.768)		0.454 (0.278~0.721)
T stage		0.190
I/II	reference
III/IV	1.354 (0.868~2.158)
Harvested lymph nodes		0.782
<22	reference
>=22	1.044 (0.771~1.410)
Lymph nodes metastasis		0.404
No	reference
Yes	1.133 (0.845~1.520)
Peripheral nerve invasion		0.423
No	reference
Yes	1.136 (0.830~1.551)
Lymphovascular invasion		0.687
No	reference
Yes	1.076 (0.751~1.532)
CEA		0.027		0.321
Negative	reference		reference
Positive	1.399 (1.038~1.885)		1.184 (0.848~1.650)
AFP		0.918
Negative	reference
Positive	0.915 (0.126~4.718)
SCC		0.270
Negative	reference
Positive	0.707 (0.370~1.283)
NSE		0.376
Negative	reference
Positive	0.872 (0.642~1.180)
CA72-4		0.783
Negative	reference
Positive	1.052 (0.729~1.508)
CA125		0.144
Negative	reference
Positive	0.681 (0.399~1.125)
CA15-3		0.980
Negative	reference
Positive	1.254 (0.652~1.674)
CA199		0.005		0.022
Negative	reference		reference
Positive	1.663 (1.168~2.364)		1.600 (1.068~2.394)
FERR		0.137
Negative	reference
Positive	0.575 (0.264~1.152)
CYFRA21-1		0.834
Negative	reference
Positive	1.036 (0.741~1.443)

OR, odds ratio; 95% CI, 95% confidence interval.

Items were included in the multivariate analysis only when P value <0.05 in univariate analysis.

The bold values represent significant difference (P < 0.05).