Table 4.

Univariate and multivariate analyses of various predictive factors for KRAS status in TNM(II/III) participants.

	Univariate Analysis OR (95% CI)	P-Value	Multivariate Analysis OR (95%CI)	P-Value
Age (years)		0.147
<65	reference
>=65	1.281 (0.916~1.787)
Gender		0.139
Female	reference
Male	0.788 (0.574~1.081)
Histology type		0.020		0.035
non-adenocarcinoma	reference		reference
adenocarcinoma	0.584 (0.415~0.824)		0.644 (0.427~0.972)
Tumor size		0.185
<=4.6cm	reference
>4.6cm	0.809 (0.591~1.106)
Tumor location		0.006		0.008
Right	reference		reference
Left	0.636 (0.459~0.881)		0.615 (0.430~0.882)
Degree of differentiation		0.002		0.002
Moderately and highly	reference		reference
Low	0.463 (0.282~0.737)		0.449 (0.268~0.729)
T stage		0.574
I/II	reference
III/IV	1.295 (0.545~3.410)
Harvested lymph nodes		0.911
<22	reference
>=22	1.018 (0.741~1.397)
Lymph nodes metastasis		0.720
No	reference
Yes	1.058 (0.776~1.445)
Peripheral nerve invasion		0.505
No	reference
Yes	1.117 (0.806~1.545)
Lymphovascular invasion		0.936
No	reference
Yes	1.015 (0.700~1.462)
CEA		0.045		0.394
Negative	reference		reference
Positive	1.379 (1.007~1.890)		1.165 (0.819~1.655)
AFP		0.647
Negative	reference
Positive	0.589 (0.029~4.627)
SCC		0.300
Negative	reference
Positive	0.704 (0.350~1.338)
NSE		0.515
Negative	reference
Positive	0.899 (0.650~1.239)
CA72-4		0.505
Negative	reference
Positive	1.138 (0.775~1.661)
CA125		0.106
Negative	reference
Positive	0.646 (0.373~1.081)
CA15-3		0.981
Negative	reference
Positive	1.232 (0.631~1.586)
CA199		0.009		0.03
Negative	reference		reference
Positive	1.634 (1.131~2.355)		1.591 (1.044~2.422)
FERR		0.242
Negative	reference
Positive	0.641 (0.291~1.308)
CYFRA21-1		0.949
Negative	reference
Positive	0.989 (0.697~1.395)

OR, odds ratio; 95% CI, 95% confidence interval.

Items were included in the multivariate analysis only when P value <0.05 in univariate analysis.