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. 2021 Jun 17;11:685065. doi: 10.3389/fonc.2021.685065

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Copyright © 2021 Shen, Liu, Bei and Xu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis of immune characteristics of immune subtypes. (A) The box plot of immune score difference in each subtype was calculated by ESTIMATE. (B) The box plot of 10 immune components difference in each subtype was calculated by MCPcounter. (C) The expression differences of 8 common immune checkpoint genes among three subtypes. (D) The difference of 6 kinds of immune cell scores in each subtype. (E) The differences of 13 kinds of immune components in different subtypes. (F) Differences of enrichment scores of four immune pathways among three subtypes. (G) Differential expression of IFN-γ related regulatory genes in three immune subtypes. **P < 0.01, ****P < 0.0001, and ns, ‘No Significant’.