FIGURE 1.

The pipeline of identification and construction of dysregulated ceRNA networks across eight cancer types. Step I: preprocessing of lncRNA, miRNA, and mRNA expression profiles from TCGA eight cancer types. Step II: identification of cancer and normal ceRNA networks using the method described in section “Materials and Methods.” Step III: extraction of ceRNA pairs that specifically existed in the cancer or normal samples. Step IV: filtration of common ceRNA pairs that occurred in both conditions using upper and lower quarters. Step V: assembling all the gain and loss interactions to construct dysregulated ceRNA networks.