Table 2.

Estimates for multivariable regression models 1, 2, and 3 for the composite fluid cognition outcome among SEARCH cohort study participants with complete covariate data (n = 1,277)

	Model 1a	P	Model 2b	P	Model 3c	P
Diabetes type: T2D vs. T1D	–9.69 (–12.00, –7.39)	<0.001	–2.84 (–5.83, 0.14)	0.06	–0.99 (–3.80, 1.83)	0.49
Sex						0.04
Female	—	—	0.90 (–0.94, 2.75)	0.33	1.81 (0.07, 3.54)
Male	—	—	Ref.		Ref.
Minority race/ethnicity						0.07
Yes	—	—	–4.68 (–6.76, –2.59)	<0.001	–1.81 (–3.82, 0.19)
No	—	—	Ref.		Ref.
Duration of diabetes (1-year increase)	—	—	–0.16 (–0.43, 0.10)	0.22	–0.15 (–0.40, 0.10)	0.23
WHtR (0.1-unit increase)	—	—	–1.76 (–2.92, –0.60)	<0.01	–1.50 (–2.59, –0.41)	<0.01
HbA1c AUC (1-unit increase)	—	—	–0.11 (–0.67, 0.45)	0.70	0.24 (–0.29, 0.78)	0.37
Any hypoglycemic events (12 months)				0.43		0.82
Yes	—	—	–1.29 (–4.49, 1.90)		–0.35 (–3.35, 2.65)
No	—	—	Ref.		Ref.
CES-D score (1-unit increase)	—	—	–0.18 (–0.28, –0.08)	<0.001	–0.20 (–0.30, –0.10)	<0.0001
Parental education				<0.01		0.53
High school graduate or less	—	—	–3.22 (–5.38, –1.06)		–0.65 (–2.72, 1.41)
Some college or more	—	—	Ref.		Ref.
Household income ($)				<0.01		0.14
<25,000	—	—	–4.63 (–7.60, –1.66)		–2.43 (–5.23, 0.38)
25,000–49,999	—	—	–1.82 (–4.62, 0.98)		–0.49 (–3.13, 2.15)
50,000–74,999	—	—	–0.02 (–3.29, 3.24)		–0.16 (–3.22, 2.91)
Do not know or refused	—	—	–4.56 (–6.96, –1.75)		–2.69 (–5.15, –0.23)
≥75,000	—	—	Ref.		Ref.
Picture Vocabulary score (1-unit increase)	—	—	—	—	0.41 (0.35, 0.48)	<0.0001

Data are presented as estimate (95% CI). Ref., referent.

^aModel 1 included the main effect for diabetes type (T2D vs. T1D). All models also adjusted for SEARCH clinical site.

^bModel 2 variables included the covariates sex, race/ethnicity, duration of diabetes, WHtR, CES-D, any hypoglycemic events in the past 12 months, parental education, household income, and glycemic control.

^cModel 3 variables included all model 1 and model 2 variables in addition to age-corrected Picture Vocabulary scores.