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. 2021 Jul;11(7):a038497. doi: 10.1101/cshperspect.a038497

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Figure 1. — Structure of influenza A virus (IAV) viral RNA (vRNA) and ribonucleoprotein (vRNP). (A) A protein-coding region in the antisense orientation is flanked by segment-specific noncoding regions (NCRs) and terminal U12 and U13 promoter regions. The bipartite conventional packaging signal, bundling signal, and incorporation signal regions are indicated by arrows. (B) Conventional model of vRNP. Predicted promoter regions, NCRs, packaging signal regions, and central coding regions in the rod-like vRNP are shown. (C) Revised model of vRNP. Secondary and/or tertiary structures composed of nucleoprotein (NP)-free vRNAs protrude from the vRNP at multiple positions.