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Uridine nucleotides are also the precursors for de novo synthesis of the thymine nucleotides. UDP to dUDP is catalyzed by ribonucleotide reductase. Subsequently, dUDP is converted to dUMP. The methylation of dUMP to generate dTMP is catalyzed by thymidylate synthase using N5,N10-methylene THF as methyl donor.
