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The purine synthesis pathway. The purine ring is built on the ribose sugar 5-phosphoribosyl-1-pyrophosphate (PRPP) as the base. Purine nucleotides synthesis begins with PRPP, which, through a series of reactions, generates the nucleotide, inosine 5′-monophosphate (IMP). (Adapted from Garrett and Grisham 1999.)
