Table 3.

Association between statin use and odds of ulcerative colitis.

Statin use status	Cases/ controls [n]	Basic modela OR [95% CI]	p -value	Full modelb OR [95% CI]	p-value
No statin use	14100/142478	Referent		Referent
Any statin use	1552 /14042	1.15 [1.08–1.22]	<0.001	1.03 [0.96–1.11]	0.38
Current statin usec	1344/12376	1.11 [1.04–1.19]	0.001	1.00 [0.93–1.07]	0.92
Cumulative statin dose, DDDd
31–325	387/3282	1.22 [1.09–1.36]	<0.001	1.12 [1.00–1.25]	0.059
326–750	424/3852	1.15 [1.03–1.28]	0.01	1.04 [0.93–1.16]	0.55
751–1500	371/3547	1.09 [0.97–1.21]	0.16	0.97 [0.86–1.09]	0.56
>1500	367/3361	1.14 [1.01–1.28]	0.031	0.99 [0.88–1.13]	0.93
ptrend e		0.33		0.13

OR, odds ratio; CI, confidence interval.

^aThe basic model controlled for the matching factors sex, age, and area or residence through conditional logistic regression.

^bThe full model was a conditional logistic model additionally adjusted for education, previous use of non-steroidal anti-inflammatory drugs [NSAIDs] or oral contraceptives, and previous history of hypertension, ischaemic heart disease, stroke, other arterial diseases, heart failure, and type 1 and type 2 diabetes.

^cCurrent use required a dispensed statin prescription in the 12 months preceding diagnosis/indexing.

^dCumulative dose among those with any statin use in WHO Defined Daily Dose [DDD].

^e p for linear trend was calculated for statin users only using the continuous variable for cumulative DDD.