Table 1.
Baseline Characteristics of Women With and Without Endometriosis (n = 219,918), Optum Clinformatics DataMart, 2000–2019a,b
| Characteristic | Endometriosis (n = 72,677) | No Endometriosis (n = 147,251) | Difference | 95% CI | ||
|---|---|---|---|---|---|---|
| No. | % | No. | % | |||
| Demographics | ||||||
| Age, yearsc | 34.0 (7.4) | 34.4 (7.4) | −0.4 | −0.4, −0.3 | ||
| Race/ethnicityb | ||||||
| White, non-Hispanic | 50,682 | 69.7 | 99,292 | 67.4 | 2.3 | 1.9, 2.7 |
| Asian, non-Hispanic | 4,304 | 5.9 | 11,769 | 8.0 | −2.1 | −2.3, −1.8 |
| Black, non-Hispanic | 8,315 | 11.4 | 16,923 | 11.5 | −0.1 | −0.3, 0.2 |
| Hispanic | 9,376 | 12.9 | 19,267 | 13.1 | −0.2 | −0.5, 0.1 |
| Region of residence | ||||||
| Northeast | 6,350 | 8.7 | 19,160 | 13.0 | −4.3 | −4.5, −4.0 |
| Midwest | 18,789 | 25.9 | 36,752 | 25.0 | 0.9 | 0.5, 1.3 |
| South | 34,982 | 48.1 | 65,779 | 44.7 | 3.5 | 3.0, 3.9 |
| West | 12,556 | 17.3 | 25,560 | 17.4 | −0.1 | −0.4, −0.3 |
| Gynecological/Reproductive Health Variables | ||||||
| Any pain symptomsd | 48,825 | 67.2 | 33,853 | 3.0 | 44.2 | 43.8, 44.6 |
| Dysmenorrhea | 23,579 | 32.4 | 6,775 | 4.6 | 27.8 | 27.5, 28.2 |
| Dyspareunia | 8,143 | 11.2 | 1,747 | 1.2 | 10.0 | 9.8, 10.3 |
| Pelvic pain | 36,391 | 50.1 | 28,652 | 19.5 | 30.6 | 30.2, 31.0 |
| Infertilitye | 25,025 | 34.4 | 18,193 | 12.4 | 22.1 | 21.7, 22.5 |
| Infertility diagnosis | 14,050 | 19.3 | 4,653 | 3.2 | 16.2 | 15.9, 16.5 |
| Infertility treatment, procedures | 16,256 | 22.4 | 11,346 | 7.7 | 14.7 | 14.3, 15.0 |
| Infertility treatment, medications | 20,429 | 28.1 | 15,567 | 10.6 | 17.5 | 17.2, 17.9 |
| Prior pregnancy | 11,133 | 15.3 | 28,289 | 19.2 | −3.9 | −4.2, −3.6 |
| Uterine fibroids | 12,368 | 17.0 | 4,676 | 3.2 | 13.8 | 13.6, 14.1 |
| Use of GnRH agonists | 6,260 | 8.6 | 562 | 0.4 | 8.2 | 8.0, 8.4 |
| Use of nonopioid analgesics | 27,747 | 38.2 | 33,794 | 22.9 | 15.2 | 14.8, 15.6 |
| Use of opioid analgesics | 43,850 | 60.3 | 47,661 | 32.4 | 28.0 | 27.5, 28.4 |
| Use of combined oral contraceptives | 25,676 | 35.3 | 58,425 | 39.7 | −4.3 | −4.8, −3.9 |
| General Pain-Related Comorbid Conditions | ||||||
| Chronic headaches (including migraine) | 12,910 | 17.8 | 21,050 | 14.3 | 3.5 | 3.1, 3.8 |
| Chronic low back pain | 15,436 | 21.2 | 25,788 | 17.5 | 3.7 | 3.4, 4.1 |
| Fibromyalgia | 4,237 | 5.8 | 6,997 | 4.8 | 1.1 | 0.9, 1.3 |
| Interstitial cystitis | 621 | 0.9 | 211 | 0.1 | 0.7 | 0.6, 0.8 |
| Irritable bowel syndrome | 3,057 | 4.2 | 2,940 | 2.0 | 2.2 | 2.0, 2.4 |
Abbreviations: CI, confidence interval; GnRH, gonadotropin-releasing hormone agonist.
a Patients were excluded if they had a prior diagnosis of depression, anxiety, or self-directed violence; prior filled prescription of an antianxiety or antidepressant medication; prior diagnosis of cancer; or prior hysterectomy.
b Data contain 4 mutually exclusive categories based on a combination of self-reported race/ethnicity and imputed race/ethnicity at the census-tract level.
c Values are expressed as mean (standard deviation).
d Includes dysmenorrhea, dyspareunia, and pelvic pain.
e Includes infertility diagnosis, procedures, medications, medical encounters, and use of GnRH antagonists.