Schroder 2008.
Study characteristics | ||
Methods | RCT, 3‐arm study Setting: Germany | |
Participants | 30 right‐handed participants with right brain damage, moderate left neglect
Experimental 1: n = 10, experimental 2: n = 10, control: n = 10
Number lost to follow‐up: none
Adequacy of matching at baseline? Yes, no significant differences at baseline
Mean age, years, mean (SD): experimental 1 = 68.4, experimental 2 = 60.6, control = 67.3
Sex (men/women): experimental 1 = 7/3, experimental 2 = 5/5, control = 6/4
Time post onset, days, mean (SD): experimental 1 = 43.8 (23.6), experimental 2 = 24.6 (9.6), control = 36.2 (24.2)
Side of damage: right
Method of diagnosing stroke: not stated
Method of diagnosing neglect
No details of cutoffs provided Inclusion criteria: right‐handedness, less than 90 days post stroke, left brain damage, at least moderate neglect Exclusion criteria: not stated Visual sensory deficit: not stated |
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Interventions | Visual exploration and TENS: 20 therapy sessions, each lasting 25 to 40 minutes over 4 weeks (TENS: 100 Hz, over left trapezius, applied throughout exploration training) vs visual exploration and OKS 20 therapy sessions, each lasting 25 to 40 minutes over 4 weeks (OKS: small randomly spaced squares moving slowly to the left across a screen, 2 × 10‐minute periods of OKS separated by 10 to 20 minutes of exploration training) vs visual exploration (control) using the ELEX apparatus (stimuli patterns were presented on a screen that subtended 53° vertically and 40° horizontally: after initial fixation, participants had to shift fixation to a yellow stimulus) Profession of the intervention provider not stated |
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Outcomes |
Measured up to 1 week post intervention |
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Notes | TENS: "a non‐specific activation of the right hemisphere or a directional effect on the egocentric coordinates of extrapersonal space" OKS "activates multiple cortical (temporoparietal and vestibular cortex, the insula) and subcortical structures (basal ganglia) involved in multisensory integration" | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | "Randomly assigned"; no other details |
Allocation concealment (selection bias) | Unclear risk | Unclear |
Blinding of participants | High risk | No details given |
Blinding of personnel | High risk | No details given |
Blinding of outcome assessment (detection bias) All outcomes | High risk | No details given |
Incomplete outcome data (attrition bias) All outcomes | Unclear risk | None reported |
Selective reporting (reporting bias) | Unclear risk | Unclear |
Other bias | Low risk | For the few variables given, groups appear comparable at baseline |