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. 2021 Jul 1;2021(7):CD003586. doi: 10.1002/14651858.CD003586.pub4

Vatanparasti 2019.

Study characteristics
Methods RCT, pilot
Setting: Iran, stroke unit
Participants Stroke patients with neglect, diagnosis of whom was verified by magnetic resonance imaging and clinical examination, right‐handed
Age, years: intervention 1 PA = 65.5 ± 10.2, intervention 2 PA + cTBS = 67.5 ± 8.4
Sex (men/women) no. (%): intervention 1 PA = 5 (70), 2 (30); intervention 2 PA + cTBS = 5 (70), 2 (30)
Time since stroke onset, no unit of measurement specified: subacute no. (%): intervention 1 PA = 3 (42.9), intervention 2 PA + cTBS = 3 (42.9)
Time since stroke onset, no unit of measurement specified: chronic no. (%): intervention 1 PA = 4 (57.1), intervention 2 PA + cTBS = 4 (57.1)
Interventions Prism adaptation + cTBS
Intervention 1: all patients were asked to wear a pair of prism glasses with a rightward prismatic shift of 10° when patients were asked to actively move their intact hand in front of a vertical mirror box for 20 minutes. Sham TMS followed the same protocol except the coil was positioned at a 90° angle to the skull, and a small part of the coil was resting on the skull
Intervention 2: in addition to prisma adaptation, 1 group of patients received 10 sessions of TMS over the intact left posterior parietal cortex
Outcomes
  • Star cancellation task

  • Line bisection task

  • Figure copying test

  • Clock drawing

  • Modified Rankin scale (MRS)


Assessed pre‐intervention and post intervention
Notes  
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk No details
Allocation concealment (selection bias) Unclear risk No details
Blinding of participants Low risk “Patients were unaware of the group assignments; they were informed that they are going to undergo the treatment for their visuospatial neglect of left side of their body”
Blinding of personnel High risk However, therapist was aware about patients’ group allocation
Blinding of outcome assessment (detection bias)
All outcomes High risk No details given
Incomplete outcome data (attrition bias)
All outcomes Unclear risk No details given
Selective reporting (reporting bias) Unclear risk Unclear
Other bias Low risk Nothing obvious