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. 2021 Jun 17;12:638694. doi: 10.3389/fimmu.2021.638694

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Copyright © 2021 Chauhan, Rathore, Sachan, Lacroix-Desmazes, Gupta, Awasthi, Vrati and Kalia

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Activation of innate immune and inflammatory responses in JEV-infected moDCs. (A) KEGG pathway enrichment analysis of the upregulated immune-related significant DEGs in JEV-infected moDCs. (B, C) Heatmap showing DEGs mapped to various innate immune and inflammatory pathways (B), and Pathogen recognition receptors (PRRs) (C), between mock and JEV-infected condition across the three donors. (D, E) Relative mRNA levels of selected PPRs (D) and innate immune/inflammatory regulators (E) was analysed in JEV-infected (5 MOI, 24 h) moDCs from four donors by qRT-PCR. Value from each donor along with the mean shown as log₂ expression normalized to mock infection.