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. 2021 Jun 17;12:638694. doi: 10.3389/fimmu.2021.638694

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Copyright © 2021 Chauhan, Rathore, Sachan, Lacroix-Desmazes, Gupta, Awasthi, Vrati and Kalia

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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JEV-infected moDCs transcriptionally downregulate PPAR/lipid and fatty acid metabolism pathways. (A) Significantly downregulated DEGs during JEV infection were subjected to KEGG pathway enrichment. (B) Heatmap showing the downregulated DEGs encoding for proteins implicated in PPAR, regulation of sterol transport and lipid biosynthesis process pathways. (C) A functional gene association network for DEGs involved in lipid biosynthetic processes was generated using STING 11.0. The line thickness (-) indicates the strength of data support.