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. 2021 Jun 17;9:670184. doi: 10.3389/fcell.2021.670184

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Copyright © 2021 Zhu, Tian, Jiang, Gao, Yu, Zhou, Yan, Ren, He and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of ferroptosis inducer on expression levels of 11-core prognostic genes in breast cancer cell lines in vitro. (A,B) The cell viability of MCF-7 (A) and MDA-MB-231 (B) treated by erastin was tested by CCK8 assay. (C,D) Lipid peroxidation of MCF-7 (C) and MDA-MB-231 (D) treated by erastin was assessed by flow cytometry after C11-BODIPY staining. (E,F) The expression changes of 11-core prognostic genes in MCF-7 (E) and MDA-MB-231 (F) after being treated with 20 μM erastin were detected by real time-PCR. (G) The expression changes of G6PD, PIK3CA, and BRD4 genes in MDA-MB-231 and MCF-7 after being treated with erastin for 48 h were detected by western blot (G6PD-H means high exposure, G6PD-L means short exposure). * P < 0.05; **P < 0.01; ***P < 0.001.