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. 2021 Jun 17;12:687869. doi: 10.3389/fimmu.2021.687869

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Copyright © 2021 Wu, Zhang, Zhang, Wang, Ding, Nie, Li, Liu, Yu, Yang, Duan, Qu, Wang and Huang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The neutralization activity of polyclonal Abs against the five epidemic variants. Sera were serially diluted and the other procedures were the same as described for Figure 2A . Scatter plot of (A–F) showing the neutralization ID₅₀ ratio of each variant to that of D614G. Each point represents a single result, and the dashed line represents the mean value. The results are a summary of at least three repeated experiments. The dotted line represents 4-fold changes. (D) showed the animal immunization scheme.