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. 2021 Jun 17;12:677746. doi: 10.3389/fphys.2021.677746

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Copyright © 2021 Barbé, Loumaye, Lause, Ritvos and Thissen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Muscle Pak1 and Pak2 mRNA levels in response to skeletal muscle hypertrophy induced by MSTN inhibition. (A) TA muscle Pak1 and (B) Pak2 mRNA levels, (C) TA and (D) GC muscle weight after one, 2 or 4 injections of sActRIIB (green columns) or PBS (white columns) in WT mice (n = 4–6/group). Results are expressed as means ± SEM. Statistical analysis was performed using unpaired t-test to compare results from sActRIIB-treated and PBS-treated mice (*P < 0.05; **P < 0.01, and ***P < 0.001 vs. CTRL).