TABLE 2.

Commonly regulated genes following MSTN inhibition.

	MSTN			FS			sActRIIB
Genes	KO	KO	KO	mTrFS	Acute	Chronic	Acute	Chronic
	Steelman et al. (2006)	Rahimov et al. (2011)	Welle et al. (2009)	Barbé et al. (2017)	Davey et al. (2016)	Davey et al. (2016)	Rahimov et al. (2011)	Rahimov et al. (2011)
	FC	FC	FC	FC	FC	FC	FC	FC
Pak1	2.1	1.7	1.6	2.0	1.8	2.9	1.5	1.7
Gdap1	1.6	1.6	1.9	2.3	1.8	1.7	1.4	X
Igfbp5	X	1.9	1.6	1.6	1.5	1.6	1.7	1.7
Mybph	2.9	1.6	X	2.5	3.3	10.6	1.6	1.6
Xrcc5	1.8	1.5	1.5	1.9	1.4	1.7	X	1.4
Inmt	−2.1	−2.9	X	−3.1	−1.8	−4.2	−2.7	−2.4
Nos1	X	−1.4	−1.4	−1.7	−2.2	−3.8	−2.2	−1.6
Lmod2	−2.1	−2.9	X	−2.5	−2.0	−3.2	−1.8	−2.0
Ddah1	−2.8	−1.5	−2.1	X	−3.3	−5.4	−1.6	−1.4
Ramp1	−1.5	−1.9	−2.1	−1.7	−1.6	−2.6	X	−1.4
A930003A15Rik	2,4	1,5	X	X	3,2	15,7	1,8	2,0
Hspb8	1.8	1.5	X	2.1	1.6	3.4	X	1.4
Atp1b4	2.2	X	X	1.8	1.7	1.7	1.7	1.5
Tbc1d1	−2.7	−1.5	X	−2.2	−2.2	−3.4	−2.3	X
Asb15	−1.6	−1.9	X	X	−1.6	−3.4	−1.9	−1.4
Itgb5	X	−1.8	X	−2.0	−1.9	−2.6	−1.6	−1.4
Skil	−1.6	X	−1.4	−2.3	−2.2	−3.2	−1.4	X
Ptpn3	−2.3	−3.1	X	X	−1.7	−2.7	−1.4	−2.0
Dusp26	X	−1.8	−1.6	−2.1	−1.5	−2.3	X	−1.6
Fxyd6	−2.3	−1.5	−1.6	−1.9	X	−2.0	X	−1.4

FC, Fold-change compared to CTRL condition; X, not found; Pak1, p21-activated kinase 1; Gdap1, Ganglioside-induced differentiation-associated-protein 1; Igfbp5, Insulin-like growth factor binding protein 5; Mybph, Myosin binding protein H; Xrcc5, X-ray repair complementing defective repair in Chinese hamster cells 5; Inmt, Indolethylamine N-methyltransferase; Nos1, Nitric oxide synthase 1; Lmod2, Leiomodin 2; Ddah1, Dimethylarginine dimethylaminohydrolase 1; Ramp1, Receptor (calcitonin) activity modifying protein 1; Hspb8, Heat shock protein 8; Atp1b4, ATPase, (Na +)/K + transporting, beta 4 polypeptide; Tbc1d1, TBC1 domain family, member 1; Asb15, Ankyrin repeat and SOCS box-containing 15; Itgb5, Integrin beta 5; Skil, SKI-like; Ptpn3, Protein tyrosine phosphatase, non-receptor type 3; Dusp26, Dual specificity phosphatase 26; Fxyd6, FXYD domain-containing ion transport regulator 6.