TABLE 3.

Determination of synergy of compound 5 with approved antibiotics.

Drug	E. coli	MIC of compound 5 in the presence of the drug (A)	MIC of the drug in the presence of compound 5 (B)	FIC A	FIC B	ΣFIC A + FIC B	Inference
Compound 5	0.64
Ciprofloxacin	0.62	0.0996	0.09652	0.1606	0.1556	0.3162	Synergistic
Gentamicin	0.52	0.0756	0.06523	0.1453	0.1254	0.2693	Synergistic
Rifampicin	0.49	0.0589	0.02569	0.1202	0.0524	0.1726	Synergistic
Doxycycline	0.36	0.0253	0.00986	0.0702	0.0273	0.0975	Synergistic