Table 2.

Change in ICSI score from baseline to week 12

	ICSI total score				Change in ICSI total score from baseline to week 12
	Week 0		Week 12
	n	Mean ± SD	n	Mean ± SD	Median	Mean ± SD	LS mean	95% CI
KRP‐116D	49	13.9 ± 3.1	48	8.7 ± 4.2	−5.0	−5.2 ± 4.4	−5.2	(−6.2, −4.2)
Placebo	47	13.7 ± 3.1	45	10.3 ± 4.0	−4.0	−3.4 ± 2.9	−3.4	(−4.5, −2.4)

Estimated difference between the groups	Difference in LS means	95% CI for difference in LS means	P
KRP‐116D vs placebo	−1.8	(−3.3, −0.3)	0.0188

Analysis set: full analysis set.