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. 2021 Feb 1;16(8):1283–1289. doi: 10.1002/cmdc.202000952

Figure 1.

Figure 1

FNT inhibitors and structure comparison of FNTs from human‐pathogenic plasmodia. A) Structures of three inhibitors for plasmodial FNT‐type l‐lactate transporters: MMV007839, BH297, and BH267.meta. B) Protein sequence similarity and identity of the human‐pathogenic plasmodial FNTs (Pf: P. falciparum, Pv: P. vivax, Pm: P. malariae, Po: P. ovale, Pk: P. knowlesi). C) Model of a PfFNT protomer as viewed from the cytoplasmic side indicating positions and the degree of sequence deviations between the human‐pathogenic plasmodial FNTs (white‐red scale). The entry site into the l‐lactate transport path is marked (orange circle) as well as the PfFNT G107 S resistance mutation position (dark cyan).