Table 1.
IC50 values of MMV007839, BH297, and BH267.meta on plasmodial FNTs and human MCT1; data for PfFNT from ref. [24].
|
|
IC50 [μM] |
||||||
|---|---|---|---|---|---|---|---|
|
|
PfFNT |
PvFNT |
PmFNT |
PoFNT |
PkFNT |
PbFNT |
hMCT1 |
|
MMV007839 |
0.17±0.01 |
0.09±0.01 |
0.15±0.01 |
0.16±0.01 |
0.45±0.07 |
0.32±0.03 |
92.8±3 |
|
BH297 |
0.11±0.01 |
0.25±0.02 |
0.38±0.02 |
0.64±0.12 |
0.99±0.08 |
0.79±0.05 |
≈100 |
|
BH267.meta |
0.11±0.01 |
0.23±0.01 |
0.21±0.02 |
0.21±0.03 |
0.87±0.06 |
0.75±0.03 |
≈500 |