Table 3:
Common molecular aberrations in B cell lymphoma.
| Lymphoma | Most common genetic alteration | Variants | Utility |
|---|---|---|---|
| DLBCL | BCL-6 translocation or mutation | BCL2(translocation), MYC(translocation) | MYC translocation infers aggressive disease |
| FL | t(14;18)(q32;q21), IGH-BCL2 | BCL6 translocation | The presence of a t(14;18), IGH-BCL2 facilitates the diagnosis |
| CLL | del(13q14) | del(11q22–23), +12, del(17p13), del(6q21) | del(13q14)-favorable prognosis, del(11q22–23), del(17p13)-unfavorable prognosis |
| MCL | t(11;14)(q13;q32) CCND1-IGH | Rare translocations involving cyclin D2 or D3 | The presence of a t (11;14), CCND1-IGH facilitate the diagnosis |
| MZL | t(11;18)(q12;q21), BIRC3-MALT1 | t(14;18)(q32;q21), IGH-MALT1 t(3;14)(p14.1;q32), FOXP1-IGH t(1;14)(p22;q32), IGH-BCL10 | t(11;18), BIRC3-MALT1 in gastric MALT lymphoma is associated with resistance to antibiotic therapy |
| BL | t(8;14)(q24;q32), MYC-IGH | t(2;8)(p12;q24), IGK-MYC t(8;22)(q24;q11), MYC-IGL | The presence of a t(8;14), MYC-IGH facilitates the diagnosis |
| Burkitt-like lymphoma with 11q aberration | -11q23.3-q25 Chromosome 11 proximal gain and telomeric losses |
Not applicable | The presence of aberration facilitates the diagnosis |
DLBCL: Diffuse large B cell lymphoma, FL: Follicular lymphoma, CLL/SLL: Chronic lymphocytic leukemia/small lymphocytic lymphoma, MCL: Mantle cell lymphoma, MZL: Marginal zone lymphoma, BL: Burkitt’s lymphoma