Table 4:
Diagnostic molecular alterations in common T-cell lymphoproliferative disorders.
| Lymphoma | Most common genetic alteration | Variants | Utility |
|---|---|---|---|
| Anaplastic Large T-Cell Lymphoma (ALCL) | t(2;5) (p23;q35) NPM1-ALK | t(x; 5) and other numerous variants ALK translocation | ALK translocations: favorable |
| Peripheral T-cell lymphoma | Gains: 7q, 8q, 17q, 22q; Losses: 4q, 5q, 6q, 9q, inv14q (q11;q32) | Losses: 10q, 12q, 13q | Not established |
| T-cell prolymphocytic leukemia | inv14q (q11;q32) | t(8;8)(p11–12;q12), trisomy 8q, idic (8p11) | inv(14q)(q11;q32) facilitates the diagnosis |
| Hepatosplenic T-cell lymphoma | i(7)(q10) | i(7)(q10) facilitates the diagnosis | |
| Enteropathy-associated T-cell lymphoma | 9q31.3 complex amplifications | del16q12.1 | 9q amplification facilitates the diagnosis |
| Extranodal NK/T-cell lymphoma, nasal type | del (6)(q21q25), i (6)(p10) | Not established |