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. 2021 Jun 17;12:645041. doi: 10.3389/fphys.2021.645041

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Copyright © 2021 Luo, Zhong, Chong, Zhang and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Trimetazidine inhibited MI-induced myocardial energy metabolism via the SIRT1–AMPK pathway in vivo. (A) Western blot analysis of SIRT1, p-AMPK, and t-AMPK. (B) ATP content in H9C2 cardiomyocytes. (C) SOD activity in H9C2 cardiomyocytes. (D–F) Contents of LPO (D), FFA (E), and NO (F) in H9C2 cardiomyocytes (N = 10 per group). All data were expressed as the mean ± standard deviation. Data were analyzed using one-way ANOVA, followed by Tukey’s multiple comparisons test. *P < 0.05. ATP, adenosine triphosphate; SOD, superoxide dismutase; LPO, lipid peroxide; FFA, free fatty acids; NO, nitric oxide.