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. Author manuscript; available in PMC: 2021 Jul 1.
Published in final edited form as: Pharmacol Res. 2021 May 4;169:105653. doi: 10.1016/j.phrs.2021.105653

Fig. 9. Functional properties displayed by Zn2+ and H+ at ZACSer128, ZACVal128, ZACIle128 and ZACPhe128 mutants expressed in oocytes.

Fig. 9.

A. The chemical structures of the side chains of the Thr, Ala, Ser, Val, Ile and Phe residues and representative traces for the current responses evoked by Zn2+ (10 mM) in ZACThr128-, ZACAla128-, ZACSer128-, ZACVal128-, ZACIle128- and ZACPhe128-expressing oocytes. B. Averaged current amplitudes evoked by Zn2+ (10 mM) in ZACThr128-, ZACAla128-, ZACSer128-, ZACVal128, ZACIle128- and ZACPhe128-expressing oocytes (mean ± S.E.M., n = 5–8) (left), and averaged concentration-relationships displayed by Zn2+ at ZACThr128, ZACSer128 and ZACVal128 (means ± S.E.M., n = 5–8) (right). C. Averaged current amplitudes evoked by H+ (pH 4.0) in ZACThr128-, ZACSer128-, ZACVal128, and ZACPhe128-expressing oocytes (mean ± S.E.M., n = 6–8). A–C. All oocytes were injected with 1.84 ng cRNA of the respective ZAC subunits.