FIGURE 1.

Schematic showing the complexity of AD research with regards to brain plasticity and neuronal network rhythms. A general summary of the type of studies is shown on top (red box), the bidirectional interplay between plasticity and oscillations within the neuronal network is shown in the middle where a very simplified schematic of a neuronal network is shown formed by connected pyramidal cells (blue circles) and interneurons (green circles). The future perspective is shown in the green box claiming a shift of the studies toward earlier time points (green horizontal arrow). On the bottom, there is a schematic timeline showing the most prominent pathological events that takes place during AD progression where electrophysiological recordings at earlier stages have revealed very early synaptic failure on the neuronal circuit’s performance. MCI: Mild cognitive impairment.