TABLE 1.
Summary of studies on LTP in AD-related models showing the diversity of approaches and the studied time point during AD progression.
| AD model | Plasticity protocol | Age of impairment studied/expression | Brain area/synapse | References |
| Cerebral microinjections of human naturally secreted Aβ42 oligomers to adult Wistar rats. | LT-HFS inducing protocol. In vivo. | NA | Hippocampal CA1 area. | Walsh et al., 2002 |
| Acute Aβ42 application to wt mice brain slices. | Theta-nested gamma oscillations induced LTP. Ex vivo. | NA | Hippocampal CA1 area. | Park et al., 2020 |
| Acute Aβ42 application to wt mice brain slices. | LTP: HFS protocol. Ex vivo. | NA | Hippocampal CA1 area. | Samidurai et al., 2018 |
| Acute Aβ42 application to wt mice brain slices. | LTP: HFS protocol. Ex vivo. | NA | Hippocampal CA1 area. | Rammes et al., 2017 |
| Acute Aβ42 application to wt mice brain slices. | LTP: TBS protocol. Ex vivo. | NA | Hippocampal CA1 area. | Zhang et al., 2017 |
| Acute Aβ42 application to wt mice brain slices. | Optogenetic induced α7 nAChR-dependent tLTP | NA | Hippocampal CA1 area. (septal input stimulation) | Gu and Yakel, 2011 |
| APPswe/PS1dE9 mice | STDP-LTP: pre-post inducing protocol. Ex vivo. | 3.5 months old | Somatosensory cortex, layer 2/3. | Shemer et al., 2006 |
| APP (KM670/671NL) / PS1 (L166P) mice | STDP-LTP: pre-post inducing protocol. Ex vivo. | 6 months old | Hippocampal CA1 area. | Garad et al., 2021 |
| AppNL-G-F mice | LTP: HFS protocol. Ex vivo. | 3–4 months old | Medial prefrontal cortex | Latif-Hernandez et al., 2020 |
| AppNL-G-F mice | Late-LTP: TBS protocol. Ex vivo. | 6–8 months old | Hippocampal CA1 | Latif-Hernandez et al., 2020 |
| 5xFAD mice | LTP: TBS protocol Ex vivo. | 6 months old | Hippocampal CA1 | Crouzin et al., 2013 |
| 5xFAD mice | LTP: TBS protocol Ex vivo. | 6 months old | Somatosensory cortex layer 5. | Crouzin et al., 2013 |
| J20 mice | LTP: TBS protocol Ex vivo | 4–6-month-old | Medial perforant path to Dentate Gyrus granule cell synapses | Zhang et al., 2017 |
| 3xTg mice | LTP: HFS protocol Ex vivo | Postnatal day 7 | Hippocampal CA1 | Joseph et al., 2019 |
| 3xTg mice | LTP: HFS protocol Ex vivo | 14–16-month-old | Hippocampal CA1 | Joseph et al., 2019 |
NA, not applicable.