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. 2021 Jun 17;15:649485. doi: 10.3389/fnins.2021.649485

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Copyright © 2021 Trifunovic, Stevanovic, Milosevic, Ristic, Janjic, Bjelobaba, Savic, Bozic, Jakovljevic, Tesovic, Laketa and Lavrnja.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Stereological analysis of the temporal changes of ACTH cells. (A) Changes in the volume of the pituitary during EAE. Variation of ACTH secreting cells in the pituitary in volume density (B), number (C), and volume of the single cell (D) in the course of EAE. Pituitary from control – C and EAE rats, obtained from different time points—Eo (onset of the disease), Ep (peak of the disease), and Ee (end of the disease), and used for determination in morphometric parameters. Results are given as means ± SEM; *p < 0.05, **p < 0.01, and ***p < 0.001 on a corresponding day.