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. 2021 Jan 27;51(4):989–994. doi: 10.1002/eji.202048978

Figure 2.

Figure 2

Type‐I IFN assessment in COVID‐19 critically ill patients using FilmArray® platform. ISG score as defined by a 4 interferon stimulated gene transcriptional signature was determined by IFN pouch FilmArray® panel, obtained from whole blood from selected patients severely infected by SARS‐CoV‐2 at ±5 days after admission in the ICU (n = 16 patients from one experiment) and healthy volunteers (n = 10 donors from one experiment). COVID‐19 critically‐ill patients are represented by a black dot, and these samples are stratified according to their impairment of IFN response. The healthy volunteers (n = 10 donors from one experiment) are represented by a black dot also. The dashed line represents the arbitrary threshold of the ISG score set to separate patients with a positive (n = 4 patients from one experiment) or negative (n = 12 patients from one experiment) IFN response. The box‐and‐whisker plots represent the median and min‐max; Mann–Whitney U test **p < 0.01; ****p < 0.0001. IFN (Interferon), ISG (Interferon Stimulated Genes).