TABLE 1.
Clinical–Paraclinical Features at the Time of PML Diagnosis in the 9 Patients Treated with T Cell Therapy
| Pt | Age, yr/Sex | Delay from Symptom Onset to PML Diagnosis (mo) | Neurological Presentation | Brain MRI Features | JC Virus DNA in the CSF, Copies/ml |
|---|---|---|---|---|---|
| 1 | 59/F | 4 | Right arm motor deficit | Single lesion in frontal prerolandic region | Negative a |
| 2 | 55/M | 4.8 | Cognitive impairment, left arm segmental ataxia | Multiple bilateral lesions in the frontal lobes, centrum semiovale, and in the posterior limb of the internal capsule | 3,950 |
| 3 | 70/F | 1.4 | Aphasia, agraphia, alexia | Single lesion involving the temporoparietal lobe | 2,440 |
| 4 | 50/M | 0.8 | Left LHH | Multiple lesions involving bilaterally the temporo‐occipital lobes and the corpus callosum | 9,000 |
| 5 | 68/M | 4 | Cognitive impairment, left LHH | Multiple lesions involving unilaterally the right parietal and occipital lobes | 2,277 |
| 6 | 54/M | 1 | Left arm motor deficit | Multiple lesions involving unilaterally the right frontal and parietal lobes | 1,024 |
| 7 | 66/M | 1 | Left hemiparesis | Multiple lesions located bilaterally in the frontal lobes | 1,300 |
| 8 | 54/F | 3.7 | Left arm segmental ataxia, nausea, gait ataxia | Multiple lesions located in the brainstem and the cerebellum | 300 |
| 9 | 17/M | 0.3 | Cognitive impairment, left hemiparesis | Multiple lesions in right parietal region, left temporoparietal regions, frontomesial region, corpus callosum, and basal ganglia | 384 |
a
This patient had 109 copies of JC virus DNA/100,000 cells on brain biopsy tissue.
CSF = cerebrospinal fluid; F = female; LHH = lateral homonymous hemianopia; M = male; MRI = magnetic resonance imaging; PML = progressive multifocal leukoencephalopathy; Pt = patient.