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. 2021 Feb 3;16(8):1290–1296. doi: 10.1002/cmdc.202000892

Figure 4.

Figure 4

Functional evidence of the P6‐2‐V3 loop interaction. A) The interaction of P6‐2 with HIV‐1 gp120 is enhanced by sCD4. B) P6‐2 inhibits binding of the coreceptor antibody 17B to HIV‐1 gp120. C) The V3 loop peptide counteracts the P6‐2‐induced inhibition of HIV‐1 infection. D) Proposed mechanism for the interference of P6‐2 with HIV‐1 entry into the host cell (modified from ref. 25). See the Experimental Section for experimental details. Error bars represent SEMs based on two experiments.