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. Author manuscript; available in PMC: 2021 Jul 1.
Published in final edited form as: Adv Exp Med Biol. 2014;791:67–81. doi: 10.1007/978-1-4614-7783-9_5

Table 5.1.

Epigenetic modifications in testicular somatic or germ cells associated with infertility or poor semen parameters

Epigenetic modification Tissue/cell type Reference
DNA methylation promoting spermatogenic defects and infertility transgenerationally Sperm Anway et al. (2005), Guerrero-Bosagna et al. (2010)
DNA methylation change at Mthfr Sperm Wu et al. (2010)
DNA methylation change at Igf2-H19 locus Sperm Boissonnas et al. (2010), Stouder et al. (2011)
DNA methylation change at Mest and Igf2-H19 locus Sperm Marques et al. (2008, 2010), Poplinski et al. (2010)
DNA methylation changes at several imprinting loci Sperm Kobayashi et al. (2007)
DNA methylation changes in several imprinted and nonimprinted genes Sperm Houshdaran et al. (2007)
Histone and DNA methylation changes in developmental and imprinted genes Sperm Hammoud et al. (2010, 2011)
Histone methylation change Sperm Steilmann et al. (2010)
Histone acetylation change Spermatids Sonnack et al. (2002)
DNA methylation change at Mthfr Testis biopsies Khazamipour et al. (2009)
DNA and histone methylation change at Faah Sertoli cell culture Grimaldi et al. (2012)
DNA methylation changes at several nuclear receptor genes Leydig cells Martinez-Arguelles et al. (2009)
DNA methylation change at several loci TM3 Leydig cell culture Singh and DuMond (2007)