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. 2021 Jun 17;12:675307. doi: 10.3389/fimmu.2021.675307

Figure 2.

Figure 2

Routine CSF parameters in different MS disease courses. (A) Frequency of elevated WBC count (≥5/μl) is higher in relapsing than progressive MS. (B) Median WBC count is higher in relapsing than progressive MS. (C) Intrathecal IgG fraction is higher in secondary progressive than relapsing MS. (D) Frequency of intrathecal IgA and IgM synthesis is lower according to Auer & Hegen than Reiber formula. (E, F) Frequency of CSF-restricted OCB is highest in definite MS. Group comparisons were performed by Mann-Whitney-U test or Pearson Chi-squared test. P values (marked as p*) were corrected for multiple comparisons after Bonferroni. CIS, clinically isolated syndrome; CSF, cerebrospinal fluid; DIS, dissemination in space; dissemination in time; IF, intrathecal fraction; Ig, immunoglobulin; MRI, magnetic resonance imaging; MS, multiple sclerosis; OCB, oligoclonal bands; PPMS, primary progressive multiple sclerosis; RRMS, relapsing-remitting multiple sclerosis; SPMS, secondary progressive multiple sclerosis.