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. 2021 Jun 17;11:652193. doi: 10.3389/fonc.2021.652193

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Copyright © 2021 Zhang, Xu, Zhao, Bao, Wang, Liu, Xu, Xiang, Jiang, Yan, Wu, Shao, Liang, Wu, Zhang, Lu and Ma

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The MPC-associated genetic alterations that can be confirmed by the validation cohort. (A) Genetic alteration profile of the validation cohort with either MPC-predominant (MPP) tumors (left panel) or other histological subtypes (right panel). (B–D) The cross-validated MPC-associated genetic changes by coupling the P values from the validation cohort with the discovery/reference cohorts that underwent different analysis: comparing MPC-dissected samples from high MPC tumors of the discovery cohort with reference cohort (B), comparing all MPC-dissected samples of the discovery cohort with reference cohort (C), and Jonckheere’s trend analysis of mutation frequency ranking from dissected samples from high MPC tumors, dissected samples from low MPC tumors, the matched non-MPC dissected samples to reference LADC samples (D). *p < 0.05, **p < 0.01.