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. 2021 Jun 17;11:652193. doi: 10.3389/fonc.2021.652193

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Copyright © 2021 Zhang, Xu, Zhao, Bao, Wang, Liu, Xu, Xiang, Jiang, Yan, Wu, Shao, Liang, Wu, Zhang, Lu and Ma

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LADC tumors with higher micropapillary contents have more T cell infiltration and immunosuppression. The pattern of immune cell infiltrations of CD4+ (A) and CD8+ (B) detected in different regions of tumor and comparison of micropapillary tumor content and the immunological markers. Upper panel: high MPC tumors vs. low MPC tumors; lower panel: the MPC percentage of the whole tumor. The Pearson’s coefficient value (r) and the corresponding P value were attached for each immunostaining; (C) The scatterplot of MPC percentage of the original tumor and the percentage of PD-L1+ cells within the MPC; (D) Graphs showing the top genetic alterations that were associated with the percentage of PD-L1+ tumors. *p < 0.05, **p < 0.01, and ***p < 0.001.