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. 2021 Jun 17;12:669642. doi: 10.3389/fphar.2021.669642

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Copyright © 2021 Xiao, Cui, Zheng, Wang, Sun, Gao, Bao, Ren, Yang, Lin, Li, Li, Yang and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Myricetin reduces the inflammatory response in BLM-treated mice. (A) Dosing regimen in BLM-induced inflammatory model. (B–C) H&E staining of left lung tissues (B, Scale: 50 μm) and inflammatory cells in BALF (C, Scale: 20 μm) of each group. (D) Total number of cells from BALF in each group. (E) Counts of macrophages in BALF. (F) Counts of lymphocytes in BALF. (G) Counts of Neutrophiles in BALF. (H–K) The expression of inflammatory factors including IL-6, IL-1α, TNF-α and IFN-γ in BALF were detected by ELISA. Data are shown as mean ± SD. # represent the difference between NaCl and BLM-treated group, ##P < 0.01, ###P < 0.001, ####P < 0.0001. * represent the difference between BLM-treated and treatment group, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.