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. 2021 Jun 17;12:622563. doi: 10.3389/fimmu.2021.622563

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Copyright © 2021 Yan, Lu, Yan and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Identification of 22 factors in the intersection of the two modules. (B) The protein-protein network and the nine factors that were most closely connected. The orange circles represent nine genes with P-values less than 0.0001 in the survival analysis. The green circles represent other genes with P-values less than 0.05 but not less than 0.001 in the survival analysis. (C) According to GO analysis, in the BP, essential genes are enriched in the IFN-γ−mediated signaling pathway and antigen processing and presentation of exogenous antigen pathway. (D) The high expression group had a higher proportion of CD8⁺ T cells infiltration, suggesting that these genes related to CD8⁺ T cells infiltration in SKCM-FPKM. (E) The high expression group had a higher proportion of CD8⁺ T cells infiltration, suggesting that these genes related to CD8⁺ T cells infiltration in GSE65904.