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. 2021 Jun 17;12:622563. doi: 10.3389/fimmu.2021.622563

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Copyright © 2021 Yan, Lu, Yan and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of gene sets with existing gene sets. (A) The 9-gene signature was positively correlated with angiogenesis, IFN-γ response, IFN-γ production, positive regulation of IFN-γ production, positive regulation of response to IFN-γ, wound healing, wound healing involved in inflammatory response, positive regulation of vascular wound healing. (B) In univariate COX regression analysis of disease-free survival of TCGA-SKCM, the gene-set of gene 9 had the most significant P value, p = 0.0005. (C) The level of 9 gene signature was higher in the immune checkpoint treatment response group of the GSE91061 cohort.