Table III.
Vaccine | Availability | Vaccine type | Excipients |
---|---|---|---|
CoronaVac (Sinovac, China) | Brasil, China (essential workers and high-risk groups), Indonesia, Turkey | Inactivated vaccine (formalin with alum adjuvant) | Aluminum hydroxide, disodium hydrogen phosphate, sodium dihydrogen phosphate, sodium chloride |
Convidicea Ad5-nCoV (CanSino Biologics, Beijing Inst. Biotech., NPO Petrovax) | China (limited to military use only), Mexico, Pakistan | Recombinant adenovirus type 5 vector against spike RBD protein | NA |
BBIBP-CorV (Sinopharm, Beijing Institute and Wuhan Institute of Biological Products) | China, Bahrain, Egypt, United Arab Emirates | Inactivated SARS-CoV-2 (vero cells) + aluminum hydroxide adjuvant | Aluminum hydroxide, disodium hydrogen phosphate, sodium dihydrogen phosphate, sodium chloride, sodium hydroxide, sodium bicarbonate, M199 |
Pfizer-BioNTech BNT162b2 | Argentina, Australia, Bahrain, Canada, Chile, Costa Rica, Ecuador, European Union, Israel, Japan, Jordan, Kuwait, Mexico, Oman, Panama, Saudi Arabia, Singapore, Switzerland, United Kingdom, United States, WHO. | mRNA-based vaccine (encoding the viral spike (S) glycoprotein) | (4-hydroxybutyl) azanediyl)bis (hexane-6,1-diyl)bis(2-hexyldecanoate)] (ALC-0315), 2-[(polyethylene glycol)-2000]-N,N-ditetradecylacetamide (ALC-0159),1,2-Distearoyl-sn-glycero-3-phosphocholine cholesterol, potassium chloride, potassium dihydrogen phosphate, sodium chloride, disodium hydrogen phosphate dihydrate, sucrose, water for injection |
Moderna mRNA-1273 | Canada, European Union, Israel, Switzerland, United Kingdom, United States | mRNA-based vaccine (encoding the prefusion stabilized spike (S) glycoprotein) | Lipids (SM-102, 1,2-dimyristoyl-rac-glycero3-methoxypolyethylene glycol-2000 [PEG2000-DMG], cholesterol, and 1,2-distearoyl-snglycero-3-phosphocholine [DSPC]), tromethamine, tromethamine hydrochloride, acetic acid, sodium acetate, and sucrose |
ChAdOx1 (Oxford/AstraZeneca; Covishield in India) | Argentina, Australia, Canada, Dominican Republic, El Salvador, European Union, India, Mexico, Morocco, United Kingdom | Replication-deficient viral vector vaccine (adenovirus from chimpanzees) | L-Histidine, L-histidine hydrochloride monohydrate, magnesium chloride hexahydrate, polysorbate 80, ethanol, sucrose, sodium chloride, disodium edetate dihydrate, water for injection |
Covaxin (BBV152) (Bharat Biotech, India) |
India | Inactivated vaccine | NA |
Sputnik V (Gamaleya Research Institute) | Russia, Palestine | Nonreplicating, 2-component vector (adenovirus) against spike (S) glycoprotein | Tris (hydroxymethyl) aminomethane, sodium chloride, sucrose, magnesium chloride hexahydrate, sodium EDTA, polysorbate 80, ethanol, water for injection |
EpiVacCorona (Federal Budgetary Research Institution State Research Ctr, Russia) | Russia | Peptide vaccine with alum adjuvant | Aluminum hydroxide, potassium dihydrogen phosphate, potassium chloride, sodium hydrogen phosphate dodecahydrate, sodium chloride, water for injection |
EDTA, Ethylenediaminetetraacetic acid; NA, Not applicable; RBD, receptor binding domain; WHO, World Health Organization,
Adapted with permission from Turner PJ, Ansotegui IJ, Campbell DE, Cardona V, Ebisawa M, El-Gamal Y, et al. COVID-19 vaccine-associated anaphylaxis: a statement of the World Allergy Organization Anaphylaxis Committee. World Allergy Organ J 2021;14:100517.4