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Mechanical loading and bone remodeling. Increased mechanical loading reduces sclerostin production from osteocytes. Sclerostin inhibits osteoblast differentiation and stimulates osteoclastogenesis at least in part by upregulation of RANKL/OPG expression. The constant mechanical loading during mastication inhibits sclerostin production from osteocytes, which may decrease bone resorption and accelerate new bone formation in the jawbone
