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. 2021 Jun 21;17(6):e1009624. doi: 10.1371/journal.pgen.1009624

Fig 7. Proposed model of Zur-regulation of VSP-II encoded genes and its effect on chemotaxis.

Fig 7

Zur forms a complex with divalent zinc ions and binds with high affinity to specific DNA sequences (black rectangle), repressing transcription of downstream genes (red line). In the absence of zur or during zinc starvation, VSP-II genes, including the vc0513-vc0515 operon are derepressed. The vc0513-encoded transcriptional activator VerA induces transcription (green arrow) of aerB, which encodes a chemotaxis receptor. AerB interacts with the chemotaxis coupling protein CheW (purple) and mediates a signal relay that alters flagellar (yellow) rotation and cell reorientation. AerB induction in minimal medium causes V. cholerae to congregate in an oxygen-dependent manner away from the air-liquid interface. Model created with BioRender.com.